AustralieFrV1, Main, Exploration, bibRecord, 008952

Tyrol Prostate Cancer Demonstration Project : early detection, treatment, outcome, incidence and mortality

Identifieur interne : 008952 ( Main/Exploration ); précédent : 008951; suivant : 008953

Tyrol Prostate Cancer Demonstration Project : early detection, treatment, outcome, incidence and mortality

Auteurs : Georg Bartsch [Autriche] ; Wolfgang Horninger [Autriche] ; Helmut Klocker [Autriche] ; Alexandre Pelzer [Autriche] ; Jasmin Bektic [Autriche] ; Wilhelm Oberaigner [Autriche] ; Harald Schennach [Autriche] ; Georg Schsfer [Autriche] ; Ferdinand Frauscher [Autriche] ; Mathieu Boniol [France] ; Gianluca Severi [Australie] ; Chris Robertson [Royaume-Uni] ; Peter Boyle [France]

Source :

BJU international : (Papier) [ 1464-4096 ] ; 2008.

RBID : Pascal:08-0214346

Descripteurs français

Pascal (Inist)
- Cancer de la prostate, Projet, Stade précoce, Pronostic, Incidence, Epidémiologie, Mortalité, Traitement, Néphrologie, Urologie.
Wicri :
- topic : Mortalité.

English descriptors

KwdEn :
- Early stage, Epidemiology, Incidence, Mortality, Nephrology, Prognosis, Project, Prostate cancer, Treatment, Urology.

Abstract

OBJECTIVE To evaluate the effectiveness of a well-controlled programme of early detection and treatment of prostate cancer in the population of Tyrol, Austria, where such a programme of early detection and treatment was initiated in 1988 and where prostate-specific antigen (PSA) testing was offered for free to all men aged 45-75 years from 1993. SUBJECTS AND METHODS Comparison of prostate cancer mortality rates in Tyrol and the rest of Austria was accomplished through a generalized additive model. A piecewise linear change-point Poisson regression model was used to compare mortality rates in Tyrol and the rest of Austria. Standardized mortality ratios were calculated with reference to the mortality rates in 1986-1990. RESULTS In all, 86.6% of eligible men have been tested at least once since 1993. Cancer deaths in Tyrol in 2005 were 54% (95% confidence interval [Cl] 34-69%) lower than expected compared with 29% (95% Cl 22-35%) in the rest of Austria. The decreasing trend in prostate cancer mortality was significantly greater in Tyrol compared with the rest of Austria (P= 0.001). A significant migration to lower stage disease occurred and radical prostatectomy was associated with low morbidity. CONCLUSIONS In the Tyrol region where treatment is freely available to all patients, where widespread PSA testing and treatment with curative intent occurs, there was a reduction in prostate cancer mortality rates which was significantly greater than the reduction in the rest of Austria. This reduction in prostate cancer mortality is most probably due to early detection, consequent down-staging and effective treatment of prostate cancer.

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
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<author><name sortKey="Robertson, Chris" sort="Robertson, Chris" uniqKey="Robertson C" first="Chris" last="Robertson">Chris Robertson</name>
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<author><name sortKey="Boyle, Peter" sort="Boyle, Peter" uniqKey="Boyle P" first="Peter" last="Boyle">Peter Boyle</name>
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<country>France</country>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Early stage</term>
<term>Epidemiology</term>
<term>Incidence</term>
<term>Mortality</term>
<term>Nephrology</term>
<term>Prognosis</term>
<term>Project</term>
<term>Prostate cancer</term>
<term>Treatment</term>
<term>Urology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Cancer de la prostate</term>
<term>Projet</term>
<term>Stade précoce</term>
<term>Pronostic</term>
<term>Incidence</term>
<term>Epidémiologie</term>
<term>Mortalité</term>
<term>Traitement</term>
<term>Néphrologie</term>
<term>Urologie</term>
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<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Mortalité</term>
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<front><div type="abstract" xml:lang="en">OBJECTIVE To evaluate the effectiveness of a well-controlled programme of early detection and treatment of prostate cancer in the population of Tyrol, Austria, where such a programme of early detection and treatment was initiated in 1988 and where prostate-specific antigen (PSA) testing was offered for free to all men aged 45-75 years from 1993. SUBJECTS AND METHODS Comparison of prostate cancer mortality rates in Tyrol and the rest of Austria was accomplished through a generalized additive model. A piecewise linear change-point Poisson regression model was used to compare mortality rates in Tyrol and the rest of Austria. Standardized mortality ratios were calculated with reference to the mortality rates in 1986-1990. RESULTS In all, 86.6% of eligible men have been tested at least once since 1993. Cancer deaths in Tyrol in 2005 were 54% (95% confidence interval [Cl] 34-69%) lower than expected compared with 29% (95% Cl 22-35%) in the rest of Austria. The decreasing trend in prostate cancer mortality was significantly greater in Tyrol compared with the rest of Austria (P= 0.001). A significant migration to lower stage disease occurred and radical prostatectomy was associated with low morbidity. CONCLUSIONS In the Tyrol region where treatment is freely available to all patients, where widespread PSA testing and treatment with curative intent occurs, there was a reduction in prostate cancer mortality rates which was significantly greater than the reduction in the rest of Austria. This reduction in prostate cancer mortality is most probably due to early detection, consequent down-staging and effective treatment of prostate cancer.</div>
</front>
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<li>Autriche</li>
<li>France</li>
<li>Royaume-Uni</li>
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<region><li>Auvergne-Rhône-Alpes</li>
<li>Rhône-Alpes</li>
<li>Victoria (État)</li>
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<settlement><li>Lyon</li>
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<name sortKey="Oberaigner, Wilhelm" sort="Oberaigner, Wilhelm" uniqKey="Oberaigner W" first="Wilhelm" last="Oberaigner">Wilhelm Oberaigner</name>
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<name sortKey="Schsfer, Georg" sort="Schsfer, Georg" uniqKey="Schsfer G" first="Georg" last="Schsfer">Georg Schsfer</name>
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<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Boniol, Mathieu" sort="Boniol, Mathieu" uniqKey="Boniol M" first="Mathieu" last="Boniol">Mathieu Boniol</name>
</region>
<name sortKey="Boyle, Peter" sort="Boyle, Peter" uniqKey="Boyle P" first="Peter" last="Boyle">Peter Boyle</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
</region>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Robertson, Chris" sort="Robertson, Chris" uniqKey="Robertson C" first="Chris" last="Robertson">Chris Robertson</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 008952 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 008952 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:08-0214346
   |texte=   Tyrol Prostate Cancer Demonstration Project : early detection, treatment, outcome, incidence and mortality
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Tyrol Prostate Cancer Demonstration Project : early detection, treatment, outcome, incidence and mortality

Tyrol Prostate Cancer Demonstration Project : early detection, treatment, outcome, incidence and mortality

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri